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Milton Keynes Formulary
Milton Keynes University Hospital NHS Foundation Trust
Bedfordshire, Luton and Milton Keynes Clinical Commissioning Group
Milton Keynes Community Health Services
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 Formulary Chapter 2: Cardiovascular system - Full Chapter
02.12  Expand sub section  Lipid-regulating drugs
 note 

NHS England and the Accelerated Access Collaborative have produced a Pathway for the management of Statin Intolerance for patients with CVD risk that has been endorsed by NICE.

 

Alirocumab (Praluent)
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Formulary
Red
Homecare
  • 75mg solution for injection in pre-filled pen, pre-filled syringe
  • 150mg solution for injection in pre-filled pen
 
Link  NICE TA393: Alirocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia
   
Bempedoic acidBlack Triangle (Nilemdo)
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Formulary
Red

180 mg film-coated tablets

For use in accordance with the NICE TA (see link below).

 
Link  NICE TA694: Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemia
   
Bempedoic acid / EzetimibeBlack Triangle (Nustendi)
(180 mg/10 mg tablets)
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Formulary
Red

Film-coated tablets, each containing 180 mg Bempedoic acid and 10 mg Ezetimibe

For use in accordance with the NICE TA (see link below).

 
Link  NICE TA694: Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemia
   
Evolocumab (Repatha )
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Formulary
Red
Homecare

140mg/mL solution for injection; pre-filled syringe 1x1mL, pre-filled SureClick pen 2x1mL

 
Link  NICE TA394: Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia
   
02.12  Expand sub section  Bile acid sequestrants
Colesevelam
(Bile Acid Malabsorption)
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Formulary
Amber 3

Cholestagel® 625mg Tablets

Notes:

  • For patients with proven Bile Acid Malabsorption (BAM) and have either failed or are intolerant of colestyramine. 
  • Off-label use.
  • The patient will be reviewed within 1 month to assess efficacy and the medication stopped if there is no improvement in symptoms or it is not tolerated.
 
Link  NICE Evidence Summary: Colesevelam for bile acid malabsorption
Link  SPS (Jun19): Shortage of Bile acid sequestrants
   
Colestipol (Colestid)
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Formulary
Amber 2

Colestid® granules for oral suspension 5g

 
Link  SPS (Jun19): Shortage of Bile acid sequestrants
   
Colestyramine
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Formulary
Green

Powder, sugar free 4g sachet 

 
Link  SPS (Jun19): Shortage of Bile acid sequestrants
   
02.12  Expand sub section  Ezetimibe
Ezetimibe
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Formulary
Green

Tablets 10mg 

 

 
Link  NICE TA385: Ezetimibe for treating primary heterozygous-familial and non-familial hypercholesterolaemia
   
02.12  Expand sub section  Fibrates
Bezafibrate
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Formulary
Green
  • Tablets 200mg
  • Tablets, modified release 400mg 
 
   
Fenofibrate
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Formulary
Amber 1
  • Capsules 67mg, 200mg, 267mg
  • Tablets 160mg
 
   
02.12  Expand sub section  Statins to top
Rosuvastatin
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Fourth Choice
Amber 2

Crestor® Tablets 5mg, 10mg, 20mg, 40mg   

Note: Restricted for 4th line use in familial hypercholesterolaemia and secondary prevention where target levels have not been met with other statins.

 
Link  Rosuvastatin PrescQIPP review
Link  Rosuvastatin QIPP further information
Link  Rosuvastatin QIPP summary
   
Atorvastatin
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Formulary
Green

Tablets 10mg, 20mg, 40mg, 80mg

 
Link  MHRA Drug Safety Update (Dec 2014)
Link  NPC: Info on simvstatin 80mg vs atorvastatin 80mg (Aug 2010)
   
Pravastatin
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Formulary
Green

Tablets 10mg, 20mg, 40mg 

 
   
Simvastatin
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Formulary
Green

Tablets 10mg, 20mg, 40mg, 80mg 

 
Link  MHRA Drug Safety Update (Dec 2014)
   
02.12  Expand sub section  Nicotinic acid group
02.12  Expand sub section  Omega-3 fatty acid compounds
 ....
 Non Formulary Items
Acipimox  (Olbetam®)

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Non Formulary
 
Atorvastatin and Ezetimibe  (Atozet)

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Non Formulary
 
Colesevelam
(Hypercholesterolaemia)

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Non Formulary
 
Fluvastatin  (Lescol®)

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Non Formulary
 
Gemifibrozil

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Non Formulary
 
Lomitapide  (Lojuxta)

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Non Formulary
High Cost Medicine
 
Nicotinic Acid  (Niaspan)

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Non Formulary
 
Nicotinic acid/ laropiprant  (Tredaptive )

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Non Formulary
Link  EMA recommends withdrawal of Tredapative
 
Omega-3-Acid Ethyl Esters
(Hypertriglyceridaemia)

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Non Formulary
 
Omega-3-Acid Ethyl Esters  (Omacor)

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Non Formulary
Link  NICE: schizophrenia - omega-3 fatty acid medicines
Link  PrescQIPP: Omega 3 fatty acids review
 
Omega-3-Marine Triglycerides  (Maxepa)

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Non Formulary
Link  NICE: schizophrenia - omega-3 fatty acid medicines
Link  PrescQIPP: Omega 3 fatty acids review
 
Simvastatin and Ezetimibe  (Inegy)

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Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Routine prescribing within licensed indication  

Amber 1

Specialist recommendation followed by GP initiation and continuation  

Amber 2

Specialist or GP initiation in line with local guideline after 1st line failure followed by GP continuation   

Amber 3

Specialist initiation and stabilisation followed by GP continuation  

Amber SCG

Specialist initiation and stabilisation followed by GP continuation in line with an agreed shared care guideline  

Red

Hospital or specialist prescribing only  

Red Red

These medicines have been evaluated and rejected by MKPAG and are NOT approved for use within MK. They are not recommended for use because of lack of clinical effectiveness, cost effectiveness or safety.  

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