netFormulary NHS
Milton Keynes Formulary
Milton Keynes University Hospital NHS Foundation Trust
Milton Keynes Clinical Commissioning Group
Milton Keynes Community Health Services
 Search
 Formulary Chapter 5: Infections - Full Chapter
Notes:

 

1. Wherever possible antibiotics should be prescribed orally

2. Antibiotics should be:

  • Administered only for as long as necessary to treat the infection
  • Changed from IV to oral as soon as possible

3. Sugar free liquids are preferred where available, and SF identifies where a sugar free product is available.

4. For young children requiring doses of less than 5ml an oral syringe will be dispensed.

 

Suspected Meningitis

Pre-admission management for suspected meningitis can be found here: http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1194947389261

Notes: 

1. All GPs should carry benzylpenicillin for injection and administer it whilst arranging the transfer of the case to hospital, unless there is a history of immediate allergic reactions after previous penicillin administration.

2. GPs do not need to carry an alternative antibiotic. However, if other antibiotics are available, a 3rd generation cephalosporin may be used. If there is a history of immediate allergic reactions to penicillin or cephalosporins, chloramphenicol may be used.

3. Immediate dose of IV/IM benzylpenicillin for suspected meningococcal infection

  • Adults and children aged 10 years or over - 1.2g
  • Children aged 1 to 9 years - 600mg 
  • Children aged under 1 year - 300mg 
Chapter Links...
 Details...
05.03.01  Expand sub section  HIV infection
Atazanavir sulfate and cobicistat (Evotaz®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Evotaz® Tablets 300mg/150mg

 
   
Emtricitabine + rilpivirine + tenofovir alafenamide (Odefsey®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tenofovir alafenamide 25mg (as fumarate) / rilpivirine
25mg/emtricitabine 200mg Odefsey® Tablet film-coated

 
   
Tenofovir alafenamide, elvitegravir, cobicistat & emtricitabine (Genvoya®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tenofovir alafenamide 10mg (as fumarate) /elvitegravir 150mg,
emtricitabine 200mg / cobicistat 150mg as Genvoya® Tablet film-coated

 
   
05.03.01  Expand sub section  Nucleoside reverse transcriptase inhibitors
Abacavir (Ziagen®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Ziagen® Tablets film-coated 300mg
  • Ziagen® Oral solution sugar free, 20mg/mL
 
   
Abacavir and Lamivudine
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Abacavir 600mg / lamivudine 300mg (Kivexa®) Tablet film-coated

 
   
Didanosine (Videx®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
  • Videx® Tablets chewable/dispersible, 25mg
  • Videx® Capsules gastroresistant 125mg, 200mg, 250mg, 400mg
  • Oral solution 10mg/mL (Unlicensed)
 
   
Emtricitabine (Emtriva®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Capsules 200mg
  • Oral solution sugar free, 10mg/mL
 
   
Emtricitabine + tenofovir alafenamide ( as fumarate) (Descovy®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Tablet film-coated, 10mg / 200mg
  • Tablet film-coated, 25mg / 200mg
 
   
Emtricitabine 200mg, Rilpivirine 25mg and Tenofovir 245mg (Eviplera®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tenofovir disoproxil 245mg (as fumarate) / rilpivirine 25mg / emtricitabine 200mg, tablet film-coated

 
   
Lamivudine (Epivir®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Tablets film-coated, 150mg, 300mg
  • Oral Solution 10mg/mL (240mL with oral syringe) 
 
   
Lamivudine (Zeffix®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tablets 100mg

 
   
Rilpivirine hydrochloride (Edurant®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tablets 25mg

 
   
Stavudine (Zerit®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
  • Capsules 20mg, 30mg, 40mg
  • Powder for oral solution, 1mg/mL (200mL)
 
   
Tenofovir 245mg, Efavirenz 600mg and Emtricitabine 200mg
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tenofovir disoproxil 245mg (as fumarate) / efavirenz 600mg/emtricitabine 200mg Atripla® Tablet film-coated

 
   
Tenofovir and Emtricitabine
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tenofovir disoproxil 245mg (as fumarate) /emtricitabine 200mg
Truvada® Tablet film-coated

 
   
Tenofovir Disproxil
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Viread® Tablets film-coated, 204mg, 245mg
  • Viread® Granules 33mg/1g
 
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
   
Tenofovir, cobicistat, elvitegravir & emtricitabine (Stribild®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tenofovir disoproxil (as fumarate) 245mg/ elvitegravir 150mg /
emtricitabine 200mg/ cobicistat 150mg as
Stribild® Tablet film-coated, 150mg/150mg/200mg/245mg

 
   
Zidovudine (Retrovir®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Capsules 100mg, 250mg
  • Retrovir® Injection, IV Concentrate for Solution for Infusion vials,
    200mg/20mL

  • Retrovir® Oral solution sugar free, 50mg/5mL (200mL)
 
   
Zidovudine and lamivudine
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Zidovudine 300mg / lamivudine 150mg as Combivir® Tablet film-coated

 
   
05.03.01  Expand sub section  Protease inhibitors
Atazanavir (Reyataz®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Capsules 150mg, 200mg, 300mg

 
   
Darunavir (Prezista®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tablets, 400mg, 600mg, 800mg

 
   
Darunavir and Cobicistat (Rezolsta®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tablets film-coated, 800mg/150mg 

 
Link  MHRA Drug Safety Update: Darunavir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1
   
Indinavir (Crixivan®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Capsules 200mg, 400mg

 
   
Lopinavir and Ritonavir (Kaletra®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Kaletra® Tablets film coated, 100mg/25mg, 200mg/50mg
  • Kaletra® Oral solution, (80mg + 20mg) per 1mL
  • Epivir® Oral solution, 10mg/mL (240mL with oral syringe)
 
   
Ritonavir (Norvir®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Tablets film-coated, 100mg
  • Oral solution sugar free, 80mg/mL
 
Link  MHRA Drug Safety Update: Ritonavir-containing products: reports of interaction with levothyroxine leading to reduced thyroxine levels
   
05.03.01  Expand sub section  Non-nucleoside reverse transcriptase inhibitors
Efavirenz
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Tablets film-coated 600mg
  • Sustiva® Capsules 50mg, 100mg, 200mg
 
   
Etravirine (Intelence®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tablets 25mg, 100mg, 200mg

 
   
Nevirapine
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare
  • Tablets 200mg
  • Viramune® Oral suspension 50mg/5mL
 
   
05.03.01  Expand sub section  Other antiretrovirals to top
Dolutegravir
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tivicay® Tablets 50mg

 
Link  MHRA: Avoid dolutegravir in women attempting to conceive
   
Dolutegravir, abacavir & lamivudine (Triumeq®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Abacavir 600mg / dolutegravir 50mg / lamivudine 300mg as Triumeq® Tablet film-coated

 
Link  MHRA: Avoid dolutegravir in women attempting to conceive
   
Enfuvirtide (Fuzeon®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Injection 108mg

Note:
90 mg/ml powder and solvent for solution for injection.
Each vial contains 108 mg enfuvirtide.
Each ml of reconstituted solution contains 90 mg enfuvirtide.

 
   
Maraviroc (Celsentri®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tablets 150mg, 300mg

 
   
Raltegravir (Isentress ®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Homecare

Tablets 400mg

 
   
 ....
 Non Formulary Items
Abacavir and Lamivudine and Zidovudine  (Trizivir®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Homecare
 
Amprenavir  (Agenerase®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Bictegravir, emtricitabine and tenofovir alafenamide  (Biktarvy®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
NHS England
 
Cobicistat  (Tybost®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Homecare
Link  MHRA Drug Safety Update (Dec 2016)
 
Fosamprenavir  (Telzir®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Lamivudine & raltegravir  (Dutrebis®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Nelfinavir  (Viracept®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Rilpiverine, emtrictabine and tenofovir alafenamide

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Saquinavir  (Invirase®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  MHRA safety advice: update on risk of arrhythmias - reduced dose for initial treatment
 
Tipranavir  (Aptivus®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Routine prescribing within licensed indication  

Amber 1

Specialist recommendation followed by GP initiation and continuation  

Amber 2

Specialist or GP initiation in line with local guideline after 1st line failure followed by GP continuation   

Amber 3

Specialist initiation and stabilisation followed by GP continuation  

Amber SCG

Specialist initiation and stabilisation followed by GP continuation in line with an agreed shared care guideline  

Red

Hospital or specialist prescribing only  

Red Red

These medicines have been evaluated and rejected by MKPAG and are NOT approved for use within MK. They are not recommended for use because of lack of clinical effectiveness, cost effectiveness or safety.  

netFormulary